发明名称 PEPTIDES FOR REGULATION OF UROKINASE (uPA) AND TISSUE TYPE (tPA) PLASMINOGEN ACTIVATOR AND METHOD OF OPTIMIZING THERAPEUTIC EFFICACY
摘要 Compositions of the polypeptide EEIIMI, Ac-RMAPEEIMDRPFLYVVR-amide, anti-LRP antibodies, LRP antagonists, and/or one or more fibrinolytic agents are formulated for enhancing the fibrinolytic activity, reducing the side effects due to vasoactivity caused by the fibrinolytic agents, and/or prologing the half lives of the fibrinolytic agents. The invention further relates to combination compositions and/or therapy regimens, comprising the polypeptide EEIIMI and/or Ac-RMAPEEIIMDRPFLYVVR-amide and one or more currently used plasminogen activators.
申请公布号 WO03095476(A3) 申请公布日期 2004.04.01
申请号 WO2003US07683 申请日期 2003.03.12
申请人 THROMBOTECH LTD.;HIGAZI, ABD-AL-ROOF;KARMALI, RASHIDA, A. 发明人 HIGAZI, ABD-AL-ROOF
分类号 A61K38/00;A61K38/02;A61K38/16;A61K38/49;A61K39/395 主分类号 A61K38/00
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