DERIVATIVES OF TRIPTOLIDE HAVING HIGH IMMUNOSUPPRESSIVE EFFECT AND HIGH WATER SOLUBILITY, AND USES THEREOF

摘要

The invention provides watersoluble triptolide derivatives of formula I, II, IIIa, and IIIb, which have high immunosuppressive effect, and in which R1 and R2 have the same meanings as claims, The invention also provides chemical method of the preparation of formula I, II, IIIa, and IIIb, and uses thereof. Formula (I), formula (II), formula (IIIa), formula (IIIb).