METHODS AND COMPOSITIONS OF NOVEL TRIAZINE COMPOUNDS

摘要

The present invention relates to methods and compositions comprising compoun ds that treat pathophysiological conditions arising from inflammatory responses . In particular, the present invention is directed to compounds that inhibit o r block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the prese nt invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditio ns characterized by smooth muscle proliferation such as restenosis and atherosclerosis.