发明名称 |
Fitness assay and associated methods |
摘要 |
The present invention provides an assay for determining the biochemical fitness of a biochemical species in a mutant replicating biological entity relative to its predecessor. The present invention further provides a continuous fluorogenic assay for measuring the anti-HIV protease activity of protease inhibitor. The present invention also provides a method of administering a therapeutic compound that reduces the chances of the emergence of drug resistance in therapy. |
申请公布号 |
AU771780(B2) |
申请公布日期 |
2004.04.01 |
申请号 |
AU19990048280 |
申请日期 |
1999.06.23 |
申请人 |
THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
JOHN W. ERICKSON;SERGEI V. GULNIK;HIROAKI MITSUYA |
分类号 |
G01N33/15;A61K31/34;A61K31/4525;A61P31/18;A61P37/04;A61P43/00;C07D493/04;C12Q1/02;C12Q1/37;(IPC1-7):C12Q1/00 |
主分类号 |
G01N33/15 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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