发明名称 |
Electroporation and electrophoresis system and method for achieving molecular penetration into cells in vivo |
摘要 |
The electroporation system and method combine pulses having different characteristics for delivering molecules to cells in vivo. The pulses include a high-intensity pulse for inducing electroporation and a low-intensity pulse to induce electrophoretic molecule movement within an interstitial space, molecule adherence to a cell membrane, and electrophoretic movement of the molecule through the permeabilized membrane. The use of a high-intensity and a low-intensity pulse achieves improved delivery; reduction of intensity and/or duration of pulses for inducing electroporation; and decreased muscle stimulation, tissue damage, and patient discomfort.
|
申请公布号 |
US6714816(B1) |
申请公布日期 |
2004.03.30 |
申请号 |
US20000507859 |
申请日期 |
2000.02.22 |
申请人 |
UNIVERSITY OF SOUTH FLORIDA |
发明人 |
HELLER RICHARD;GILBERT RICHARD;JAROSZESKI MARK J.;HELLER LOREE C.;LUCAS MELINDA L. |
分类号 |
A61N1/32;(IPC1-7):A61N5/00 |
主分类号 |
A61N1/32 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|