Antibiotic coating of porus materials by the introduction of solutions containing dodecyl sulphates or dodecyl sulphonates of various antibiotics

摘要

Disclosed is a process for the antibiotic coating of elements with interconnecting microcavities. The process comprises introducing a solution containing either gentamicin dodecyl sulfate with 1 to 5 dodecyl sulfate groups per gentamicin molecule, or gentamicin dodecyl sulfonate with 1 to 5 dodecyl sulfonate groups per gentamicin molecule into the microcavities and after vaporization or evaporation of the solvent, a layer of gentamicin dodecyl sulfate or gentamicin dodecyl sulfonate rises to the surface of the microcavities. Articles made of such elements are particularly suitable for applications like implants, such those used in the correction of bone and soft tissue damage, wound dressing, and other such medical uses.