GENE SEGREGATION AND BIOLOGICAL SAMPLE CLASSIFICATION METHODS

摘要

General methods of biological sample classification based on gene expression analysis are described. The methods segregate individual samples into distin ct classes using quantitative measurements of expression values for selected se ts of genes in individual samples compared to a reference standard. Samples displaying positive and negative correlations of the gene expression values with the reference standard samples exhibit distinct behaviors and pathohistological features. Also disclosed are methods for identifying sets of genes whose expression patterns are correlated with a phenotype. Such sets a re useful for characterizing cellular differentiation pathways and states and f or identifying potential drug discovery targets.