| 摘要 |
Micron and submicron microparticles prepared with whole, untreated serum as a dispersing agent or surfactant to reduce aggregation and facilitate treatment and administration of localized injury or disease with reduced tendency of adverse immune response. Also disclosed are processes for preparing biodegradable and biocompatible microparticle compositions by emulsifying a solution of polymer dissolved in an organic solvent with a dispersing agent, preferably porcine serum, human serum or a serum autologous to the recipient being treated, in water. The organic solvent is removed, resulting in the formation of solid particles containing active agent. Lyophilized particles can be redispersed using whole, untreated serum according to methods of the invention. The microparticle compositions may be administered to patients for treatment of localized injury or disease.
|
