发明名称 |
FACTORS THAT BIND INTESTINAL TOXINS |
摘要 |
Methods for neutralizing bacterial toxins such as Shiga toxins and cholera toxins are disclosed. In a particular embodiment, a method is provided for treating a subject suffering from an infection caused by an Stx-producing organism by administering a therapeutically effective amount of a hop bract tannin obtained from Humulus lupulus. Also provided are methods for isolatin g polyphenolic compounds that bind Stx molecules, and methods for detecting th e presence of Stx molecules in a biological sample. In a disclosed embodiment, a subject infected with a Shiga toxin-producing E. coli strain is treated by enterically administering a high molecular weight fraction of hop bract extract to the subject.
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申请公布号 |
CA2498225(A1) |
申请公布日期 |
2004.03.25 |
申请号 |
CA20032498225 |
申请日期 |
2003.09.09 |
申请人 |
CHIBA UNIVERSITY;THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SEC RET |
发明人 |
NODA, MASATOSHI;MOSS, JOEL |
分类号 |
A01N43/16;A61K;A61K45/06;(IPC1-7):A01N43/16 |
主分类号 |
A01N43/16 |
代理机构 |
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主权项 |
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地址 |
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