发明名称 |
Novel substituted indolines with an inhibitory effect on various kinases and complexes of CDKs |
摘要 |
The present invention relates to new substituted indolinones of general formula wherein X and R1 to R5 are defined as in claim 1, the isomers and the salts thereof which have valuable properties. The above compounds of general formula I wherein R1 denotes a hydrogen atom, a C1-3-alkyl group or a prodrug group have valuable pharmacological properties, particularly an inhibiting effect on various kinases, on viral cyclin and on receptor tyrosine kinases, and the other compounds of the above general formula I wherein R1 does not represent a hydrogen atom, a C1-3-alkyl group or a prodrug group are valuable intermediate products for the preparation of the abovementioned compounds.
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申请公布号 |
US2004058978(A1) |
申请公布日期 |
2004.03.25 |
申请号 |
US20030666643 |
申请日期 |
2003.09.19 |
申请人 |
BOEHRINGER INGELHEIM PHARMA KG |
发明人 |
WALTER RAINER;GRELL WOLFGANG;HECKEL ARMIN;HIMMELSBACH FRANK;EBERLEIN WOLFGANG;ROTH GERALD;VAN MEEL JACOBUS C. A.;REDEMANN NORBERT;SPEVAK WALTER;TONTSCH-GRUNT ULRIKE;VON RUEDEN THOMAS |
分类号 |
C07D401/12;A61K31/40;A61K31/403;A61K31/4035;A61K31/404;A61K31/4427;A61K31/4439;A61K31/454;A61K31/496;A61K31/506;A61K31/5377;A61K31/541;A61P35/00;A61P43/00;C07D;C07D209/34;C07D209/36;C07D209/48;C07D401/14;C07D403/12;(IPC1-7):C07D209/36 |
主分类号 |
C07D401/12 |
代理机构 |
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代理人 |
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地址 |
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