发明名称 |
PALATABLE ORAL SUSPENSION AND METHOD |
摘要 |
<p>A drug formulation in the form of a dry powder is provided which when mixed with water forms a palatable oral suspension substantially free of bitter taste, the dry powder being formed of a drug, preferably des-quinolone, which in solution has a bitter taste, and a pH modifying agent which is preferably an alkaline material such as L-arginine, where upon mixing the dry-powder in water causes the drug to have reduced solubility or precipitate in-situ to form a palatable oral suspension essentially free of bitter taste. An oral suspension, methods for making same and a method for masking the bitter taste of drugs employing one or more pH modifying agents are also provided.</p> |
申请公布号 |
WO03077842(A3) |
申请公布日期 |
2004.03.25 |
申请号 |
WO2003US06855 |
申请日期 |
2003.03.06 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY;ULLAH, ISMAT;WILEY, GARY, J. |
发明人 |
ULLAH, ISMAT;WILEY, GARY, J. |
分类号 |
A61K9/00;A61K31/4709;A61K47/18;(IPC1-7):A01N25/00;A01N25/34;A61K31/475;A61K9/14 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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