Papilloma virus vaccine

摘要

Method of prodn. of papilloma virus (PV) like particles (VLPs) comprises: (a) constructing one or more recombinat DNA molecules which each encode papilloma virus L1 protein or a combination of papilloma virus L1 protein and papilloma virus L2 protein and (b) transfecting a suitable host cell with the one or more recombinant DNA molecules so that VLPs are produced within the cell after expression of the L1 or combination of L1 and l2 proteins. Also claimed are ; (a) VLPs derived from papilloma virus contg. proteins L1 and L2; (b) VLPs derived from HPV16 contg. proteins L1 and L2; (c) VLPs derived from BPV1 contrg. proteins L1 and L2 (d) VLPs derived from BPV1 contg. protein L1; (e) VLPs derived from HPV11 contg. protein L1; (f) VPs derived from HPV6b contg. proteins L1 and L2; (g) VLPs derived from HPV6b contg. protein L1; (h) plasmid pLC201; (i) viruses doubly recombinant for PV capsid proteins L1 and L2; (j) viruses recombinant for PV capsid protein L1; (k) plasmid pLC200; (l) 5'-CAGATCTATGTCTCTTT -GGCTGCCTAGTGAGGCC-3'; (m) 5'-CAGATCTAATCAGCTTA -CGTTTTTTGCGTTTAGC-3'; (n) pLC 201 VV; etc.