| 发明名称 |
Protein kinase domain of the large subunit of herpes simplex type 2 ribonucleotide reductase (icp10pk) has anti-apoptotic activity |
| 摘要 |
The invention relates to a method of treating neuronal apoptosis in a mammal using nucleic acid encoding HSV-2 ICP10PK, or a polypeptide encoded thereby. The invention further relates to a method of treating neuronal apoptosis in a mammal using ICP10PK in combination with a nucleic acid encoding bcl-2, or the polypeptide encoded thereby. The invention also relates to the use of ICP10PK and ICP10PK in combination with bcl-2 to treat non-neuronal diseases characterized by apoptosis.
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| 申请公布号 |
US2004053868(A1) |
申请公布日期 |
2004.03.18 |
| 申请号 |
US20030333607 |
申请日期 |
2003.01.22 |
| 申请人 |
AURELIAN LAURE;PERKINS DANA;SMITH CYNTHIA |
发明人 |
AURELIAN LAURE;PERKINS DANA;SMITH CYNTHIA |
| 分类号 |
A61K38/16;A61K38/17;A61K48/00;C12N15/869;(IPC1-7):A61K48/00 |
主分类号 |
A61K38/16 |
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