Methods for identifying target genes, gene expression profiles, and biochemical/signal transduction pathways associated with specific patterns of hemodynamic shear stress and atherogenesis and uses thereof

摘要

Differentially expressed genes and profiles of differentially expressed genes associated with hemodynamic shear stress in vivo in mammalian vasculature are provided. Methods for identifying such profiles and using these profiles to identify and target regions of the vasculature with anti-atherogenic therapies are provided. Also provided are methods of identifying agents which modulate a gene of the profile for use in preventing atherogenesis and treating atherosclerosis.