发明名称 |
ZINC TRANSPORTER COMPOSITIONS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES |
摘要 |
<p>The present invention relates to the use of ZnT-1, originally described as a zinc transporter, in the regulation of L-type calcium channels (LTCC). In this study, the inventors have unexpectedly demonstrated that ZnT-1 physically interacts with LTCC, regulating its function. Most importantly, the inventors have shown that ZnT-1 can regulate intracellular Ca2+ influx, and thus, its intracellular concentration. This is the first demonstration of a natural blocker for LTCC, and it is a promising breakthrough as a potential agent to be used in the treatment and/or prevention of cardiovascular diseases and related indications.</p> |
申请公布号 |
WO2004022085(A1) |
申请公布日期 |
2004.03.18 |
申请号 |
WO2003IL00742 |
申请日期 |
2003.09.08 |
申请人 |
BEN-GURION UNIVERSITY OF THE NEGEV;SEKLER, ISRAEL;HERSHFINKEL, MICHAL;SILVERMAN, ZE'EV;MORAN, ARIE |
发明人 |
SEKLER, ISRAEL;HERSHFINKEL, MICHAL;SILVERMAN, ZE'EV;MORAN, ARIE |
分类号 |
A61P9/10;A61K38/17;A61P9/12;(IPC1-7):A61K38/17 |
主分类号 |
A61P9/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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