CARBAZOLE DERIVATIVES AND THEIR USES AS HEPARANASE INHIBITORS

摘要

Carbazole derivatives having at the 9-position a 3-(substituted)amino-2-hydroxypropyl group and fluorene derivatives having at the 9-position a =N-NH-R4 group, wherein R4 is a (substituted) carboxamido, (substituted) thiocarboxamido or (substituted) hydrazido group, are provided as heparanase inhibitors suitable for the treatment of diseases and disorders caused by or associated with heparanase catalytic activity such as cancer, inflammatory disorders and autoimmune diseases.