发明名称 |
PROCESS FOR THE MANUFACTURE OF OPTICALLY ACTIVE 3-SUBSTITUTED LACTAMS BY ASYMMETRIC HYDROGENATION OF 3-ALKYLIDENELACTAMS |
摘要 |
The present invention relates generally to processes for the efficient production optically active 3-substituted lactams of formula (I) [Insert chemical formula here] process, comprising: contacting a compound of formula (II): [Insert chemical formula here] with hydrogen under a suitable pressure in the presence of an iridium complex of the formula (R<2>)IrL<+>X<-> wherein L is a chelating diene, X is a non coordinating anion, and R<2> is selected from . [Insert chemical formula here] |
申请公布号 |
WO03079975(A3) |
申请公布日期 |
2004.03.18 |
申请号 |
WO2003US07811 |
申请日期 |
2003.03.15 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY;NUGENT, WILLIAM, A.;YUE, TAI, Y. |
发明人 |
NUGENT, WILLIAM, A.;YUE, TAI, Y. |
分类号 |
B01J31/24;C07B53/00;C07B61/00;C07D207/26;C07D207/263;C07D207/267;C07D211/76;C07D223/10;C07D405/06 |
主分类号 |
B01J31/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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