| 摘要 |
<p>Compounds of the formula (I) wherein R1, R2, R1 and R2 are independently hydrogen or a group releasing the free aminein vivo, R6 is a substituted phenyl or an optionally substituted, bicyclic or tricyclic aryl ring system or an optionally substituted mono, bi- or tricyclic heteroaryl ring system having utility as dihydrofolate reductase (DHFR) inhibitors with favourable pharmacokinetic properties.</p> |
