发明名称 |
Method for controlling the release of granules |
摘要 |
A method of controlling granule secretion comprising performing a treatment to increase or decrease an active form of calgranulin on a cell line having capability of secreting granules, thereby increasing or decreasing granule secretion from the cell line.A method of detecting a substance which inhibits or activates the granule secretion reaction by applying this controlling method. An active form of calgranulin is increased by making the cells permeabilized cells and adding a calgranulin and soluble calcium. Decrease of an active form of calgranulin is carried out by introducing a calgranulin antibody into cells.The method is useful for screening a substance which inhibits or activates granule secretion.
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申请公布号 |
US6706683(B1) |
申请公布日期 |
2004.03.16 |
申请号 |
US20010806382 |
申请日期 |
2001.03.29 |
申请人 |
ASAHI KASEI PHARMA CORPORATION |
发明人 |
SETO MINORU;FUKUDA KOUICHIROU |
分类号 |
C12N15/16;G01N33/50;(IPC1-7):C12N15/16;C12N5/06;A61K33/00 |
主分类号 |
C12N15/16 |
代理机构 |
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主权项 |
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地址 |
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