THE USE OF PROTON SEQUESTERING AGENTS IN DRUG FORMULATIONS

摘要

Methods are provided for preparing spray-dried, drug-containing particles comprising the steps of: (a) selecting a drug, an aqueous solution, and a proton-sequestering agent; (b) adding the drug and the proton-sequestering agent to the solution to form a feed solution; and(c) spray drying the feed solution to form the spray- dried, drug-containing particles, wherein at least a portion of the proton-sequestering agent remains mixed with the drug in the spray-dried, drug containing particles. particles and pharmaceutical formulations comprising the prepared particles as well as methods of use are also provided.