EDG-RECEPTOR AGONIST FOR THE TREATMENT OF HYPERTENSION

摘要

Treatment and /or prophylaxis of hypertension involving administering a therapeutically active amount of an edg-receptor agonist or a pharmaceutically acceptable salt thereof. Preferably the edg-receptor agonist is a highly selective l1-receptor agonist and essentially devoid of alpha2-receptor agonist activity and has an imidazoline structure. Hence, hypertension may be treated without causing alpha2-receptor induced side effects. The invention also provides appropriate screening tools for identifying compounds acting with high selectivity as l1-receptor agonists however lacking alpha2-receptor induced side effects. Furthermore, the receptor, membranes and cells comprising said receptor, and assays for screening compounds with said receptor are discussed in the context of the invention.