发明名称 |
IMMUNOGENIC COMPOSITION COMPRISING AN IL-13 ELEMENT AND T CELL EPITOPES, AND ITS THERAPEUTIC USE |
摘要 |
The present invention relates to isolated immunogens and their use in the treatment of diseases that are treatable with neutralisation of IL-13, such as COPD, asthma and atopic disorders such as hayfever, contact allergies and atopic dermatitis. In particular the invention relates to the neutralisation of the biological effects of IL-13 by raising an immune response against the IL-13 by vaccination of a mammal with immunogens comprising the native or mutated amino acid sequence of IL-13, and foreign T-helper epitopes either inserted in, or attached to the IL-13 sequence or present in carrier polypeptides. Also provided by the present invention are DNA vaccines that comprise a polynucleotide sequence that encodes the immunogens of the presen t invention. The invention further relates to pharmaceutical compositions comprising such immunogens and their use in medicine and to methods for thei r production.
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申请公布号 |
CA2496409(A1) |
申请公布日期 |
2004.03.11 |
申请号 |
CA20032496409 |
申请日期 |
2003.08.28 |
申请人 |
GLAXO GROUP LIMITED |
发明人 |
ELLIS, JONATHAN HENRY;ASHMAN, CLAIRE |
分类号 |
A61K39/00;A61P11/00;A61P37/08;C07K14/54;(IPC1-7):C07K19/00;A61K39/385;A61P37/06 |
主分类号 |
A61K39/00 |
代理机构 |
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主权项 |
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地址 |
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