摘要 |
<p>A method for the production of acetylene alcohols by mono-ethynylation of ketones comprising: (a) reaction of lithium with a 1-10C alkyl halide; (b) introduction of acetylene gas; and (c) addition of the ketone. A method for the production of acetylene alcohols of formula (I) by mono-ethynylation of ketones of formula R1-CO-R2 comprising: (a) reaction of lithium with a 1-10C alkyl halide, (b) introduction of acetylene gas and (c) addition of the ketone. HCequivalent toC-CR1R2-OH (I) R1, R2 = H or optionally unsaturated 1-30C alkyl, aryl, cycloalkylalkyl or cycloalkyl (all optionally substituted), or groups of formula -CH2CH2CHR3R4 or -CH2CH=CR3R4; and R3, R4 = H or optionally unsaturated, optionally substituted 1-30C alkyl, aryl, cycloalkylalkyl or cycloalkyl.</p> |