发明名称 Methods of using phenylmethylbenzoquinone and hydroquinone compounds for treatment of myocarditis, dilated cardiomyopathy and heart failure
摘要 A method for prevention or treating myocarditis, dilated cardiomyopathy and heart failure comprising administering to a patient in need of such treatment a NF-kappaB inhibitor in a therapeutically effective amount, wherein said NF-kappaB inhibitor is a benzoquinone derivative represented by the following formula (I):whereinR1, R2 and R3 are each independently a hydrogen atom, an alkyl group having 1 to 5 carbons or an alkoxy group having 1 to 5 carbons;R<4 >is a hydrogen atom, a hydroxymethyl group, an alkyl group, or a carboxyl group which is optionally esterified or amidated;Z isand n is an integer from 0 to 6,or its hydroquinone form, or a pharmaceutically acceptable salt thereof, is provided.
申请公布号 US6703421(B1) 申请公布日期 2004.03.09
申请号 US20010856072 申请日期 2001.05.17
申请人 DAIICHI SUNTORY PHARMA CO., LTD. 发明人 NUNOKAWA YOICHI;MATSUMORI AKIRA
分类号 A61K31/00;A61K31/122;A61K31/165;A61K31/192;A61K31/216;A61K31/519;A61K31/52;A61P9/04;(IPC1-7):A61K45/00 主分类号 A61K31/00
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