| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide an improved FRET hybridization probe designed so that an absolute signal is not affected by the base composition and sequence of a target nucleic acid. <P>SOLUTION: A FRET hybridization probe pair is a FRET hybridization probe pair comprising a substantially complementary nucleotide sequence substance to the target nucleic acid sequence, a fluorescence substance being either one of a FRET donor substance or a FRET acceptor substance, and a spacer substance connecting the nucleotide substance with the fluorescence substance respectively. The FRET hybridization probe pair is adjacently hybridizable to the target nucleic acid sequence. The spacer substances between the two members of the FRET hybridization probe pair can mutually form non-covalent bonding interaction. <P>COPYRIGHT: (C)2004,JPO |
