CALCIUM RECEPTOR MODULATING COMPOUND AND USE THEREOF

摘要

There is provided a calcium receptor modulator comprising a compound of the formula (I): wherein ring A is an optionally substituted 5- to 7- membered ring; ring B is an optionally substituted 5- to 7- membered heterocyclic ring; X<1> is CR<1>, CR<1>R<2>, N or NR<13>; X<2> is N or NR<3>; Y is C, CR<4 >or N, Z is CR<5>, CR<5>R<6>,< >N or NR<7>; Ar is an optionally substituted cyclic group; R is H, an optionally substituted hydrocarbon group, etc.; and --- is a single bond or a double bond; R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7 >and R<13 >are independently H, an optionally substituted hydrocarbon group; or a salt thereof or a prodrug thereof. Compounds of the formula (II) and (III): wherein ring A is an optionally substituted 5- to 7- membered ring; Q is C, CR<5> or N; R<8>, R<9>,R<10>, R<11 >and R<12 >are independently, H, an optionally substituted hydrocarbon group, etc., or a salt thereof are also provided. Also specify X<1>, R<3>, R<1>, Y and X<3> in formula (II) and (III) as before.