ENANTIOMERS OF N-(2,6-DIMETHYLPHENYL)-1-PROPYL-2-PIPERIDINOCARBOXAMIDE; ITS PHARMACEUTICAL COMPOSITIONS AND PROCESSES OF MAKING THEM

摘要

The present invention describes a method of separation of the enantiomers of N-(2,6-dimethylphenyl)-1-propyl-2-piperidinocarboxamide.Another object of the present invention refers to the enantiomeric manipulation of the enantiomers of N-(2,6-dimethylphenyl)-1-propyl-2-piperidinocarboxamide, in order to achiever compounds and pharmaceutical compositions presenting diverse enantiomeric excesses of (S)- N-(2,6-dimethylphenyl)-1-propyl-2-piperidinocarboxamide, in order to quantify and determine the participation of (R)- N-(2,6-dimethylphenyl)-1-propyl-2-piperidinocarboxamide in the anesthetic and cardiotoxic effects. These compounds and compositions enantiomerically manipulated demonstrate to present a significant improvement in itsanesthetic properties, presenting a cardiotoxic profile equivalent to pure enantiomer, a (S)- N-(2,6-dimethylphenyl)-1-propyl-2-piperidinocarboxamide.