发明名称 |
COMBINATION OF A PDE4 INHIBITOR AND TIOTROPIUM OR DERIVATE THEREOF FOR TREATING OBSTRUCTIVE AIRWAYS. |
摘要 |
<p>The present invention relates to a combination of therapeutic agents useful in the treatment of obstructive airways and other inflammatory diseases comprising (I) a PDEIV inhibitor that is therapeutically effective in the treatment of said diseases when administered by inhalation; together with (II) an anti-cholinergic agent comprising a member selected from the group consisting of tiotropium and derivatives thereof that is therapeutically effective in the treatment of said diseases when administered by inhalation; as well as to a method of treating said obstructive airways and other inflammatory diseases comprising administering to said mammal by inhalation a therapeutically effective amount of said combination of therapeutic agents; and a pharmaceutical composition comprising a pharmaceutically acceptable carrier together with said combination of therapeutic agents; and a package containing a pharmaceutical composition for insertion into a device capable of simultaneous or sequential delivery of said pharmaceutical composition in the form of an aerosol or dry powder dispersion to said mammal, where said device is a metered dose inhaler or a dry powder inhaler. It is preferred that said anti-cholinergic agent component be tiotropium bromide.</p> |
申请公布号 |
MXPA03010791(A) |
申请公布日期 |
2004.03.02 |
申请号 |
MX2003PA10791 |
申请日期 |
2002.05.23 |
申请人 |
BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG. |
发明人 |
ROISIN A. ARMSTRONG |
分类号 |
C07D451/10;A61K9/00;A61K9/12;A61K31/46;A61K45/06;A61P11/00;A61P11/06;A61P11/08;A61P25/02;A61P29/00;A61P43/00;C07D471/14;(IPC1-7):A61K31/437;A61K9/72 |
主分类号 |
C07D451/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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