CONDENSED HETEROCYCLIC COMPOUNDS AS PDE-IV INHIBITORS FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS

摘要

The present invention relates to novel heterocyclic compounds that inhibit phosphodiesterase type 4 (PDE4). The compounds are useful for treating inflammatory conditions, diseases of the central nervous system and insulin resistant diabetes , (formula I) wherein P is selected from the group consisting of bond, oxygen, sulfur and NR<1>; wherein P<1> is selected from the group consisting of hydrogen, halogen atom, -OR<1>, -S(O)mR<1>, -C(O)R<1>, formly amine, nitro and -NRR. R2 is selected from the group consisting of hydrogen, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, CN, -CH=CR<3>R<3>. The ring "A" is selected from the group consisting of substituted or unsubstituted aryl ring, and optionally substituted saturated or unsaturated five to seven membered heterocyclic ring containing one or more heteroatoms selected from the group consisting of O, S, and NR<1>; wherein R<1>, R, R and R<3> are as defined in the description.