摘要 |
The present invention relates to the use of compounds of the general Formula (I), for the regulation of the quorum sensing system of microorganisms wherein in Formula (I), R is H, alkyl, cycloalkyl, aryl or heteroaryl; R<1> is H, alkyl, cycloalkyl, aryl or heteroaryl; R<2> is H, alkyl, cycloalkyl, aryl or heteroaryl; A<1> and A<2> each independently represent an optionally substituted C1-C20-alkyl group which may contain one or more group(s) Z, or a monocyclic or polycyclic optionally substituted aromatic or non-aromatic ring system which may contain one or more group(s) X, and in case of a polycyclic ring system, said system contains at least one aromatic ring; Z is selected from the group consisting of S, O, N, NR<4>, CO, CO2, CS, SO or SO2 X is selected from the group consisting of S, O, N, NR<4>, SO or SO2; said substituted ring system carries a substituent R<3> on one or more of the carbon atoms of said ring system;said substituted C1-C20-alkyl group carries a substituent R<3> on one or more of the carbon atoms of said alkyl group; R<3> is independently H, OR<4>, SR<4>, hydroxyalkyl, hydroxyalkylamino, cycloalkyl, halogen, haloalkyl, haloalkyloxy, NO2, CN, SO2NR<4>R<5>, CO2NR<4>R<5>, COR<4>, CO2R<4>, SO2R<4>, SO3R<4>, NR<4>R<5>, alkyl, aryl or heteroaryl; R<4> is H, alkyl, cycloalkyl, aryl or heteroaryl; R<5> is H, O-alkyl, O-aryl, alkyl, heteroaryl or aryl; Y<1> and Y<2> are independent from each other C=O, C=S, SO<2> or C=NR<5>; p is 0, m is 0, n is 0; or p is 0, m is 0, n is 1;or p is 0, m is 1, n is 1; or p is 1, m is 0, n is 0; or p is 1, m is 0, n is 1; or p is 1, m is 1, n is 1.
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