发明名称 |
GENE THERAPY FOR CRITICAL LIMB ISCHEMIA WITH WILD TYPE OR MUTANT ENOS |
摘要 |
The present invention provides novel methods of preventing, diagnosing, and treating Critical Limb Ischemia (CLI), using eNOS polypeptides and polynucleotides to modulate eNOS activity in cells. Wild-type and mutant eNO S polypeptides, and polynucleotides encoding such polypeptides, are provided f or use in the methods of the present invention. The eNOS mutant polypeptides of the present invention have at least one mutation corresponding to a site in a functional domain of a mammalian eNOS that is phosphorylated in cells.</SDOA B>
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申请公布号 |
CA2494845(A1) |
申请公布日期 |
2004.02.26 |
申请号 |
CA20032494845 |
申请日期 |
2003.08.15 |
申请人 |
SCHERING AKTIENGESELLSCHAFT |
发明人 |
DOLE, WILLIAM P.;KAUSER, KATALIN;RUBANYI, GABOR;QIAN, HU SHENG |
分类号 |
C12N15/09;A61K38/22;A61K38/27;A61K38/43;A61K48/00;A61P9/00;A61P9/08;C12N9/00;C12N9/02;(IPC1-7):A61K48/00;A61P9/10;A61K38/44;A61K31/708 |
主分类号 |
C12N15/09 |
代理机构 |
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地址 |
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