4-HYDROXPIPERIDINE DERIVATIVE WITH ANALGETIC ACTIVITY

摘要

A compound represented by the following Formula (I): <CHEM> (wherein A represents oxygen atom or -NR<3>- (R<3> represents hydrogen atom or lower alkyl group); R<1> represents nitro group, lower alkoxycarbonyl group, carbamoyl group unsubstituted or mono- or di-substituted by lower alkyl group, unprotected or protected hydroxyl group, unprotected or protected carboxyl group, lower alkyl group substituted by unprotected or protected hydroxyl group, or tetrazolyl group; and R<2> represents hydrogen atom, cyano group or lower alkylsulfonyl group, provided that when A is - NR<3>-, it is excluded that R<1> represents unprotected or protected hydroxyl group or lower alkyl group substituted by unprotected or protected hydroxyl group) or its salt, and method for producing the compound, and a pharmaceutical composition containing the compound as active ingredient.