| 摘要 |
The present invention relates to conjugates comprising a polyglutamic acid polymer covalently bonded to a camptothecin molecule selected from the group consisting of 20(S)(+)-camptothecin, 9-aminocamptothecin, 9-nitrocamptothecin, 7-ethyl-10-hydroxycamptothecin, 9-dimethyl-aminomethyl-10-hydroxycamptothecin and 7-methylpiperizinomethyl-10,11-ethylenedioxy-camptothecin. The present invention also relates to such compounds as medicaments, in particular for the treatment of cancer. <IMAGE> |
