发明名称 |
Methods and compositions relating to polypeptides with RNase III domains that mediate RNA interference |
摘要 |
The present invention concerns methods and compositions involving RNase III and polypeptides containing RNase III domains to generate RNA capable of triggering RNA-mediated interference (RNAi) in a cell. In some embodiments, the RNase III is from a prokaryote. RNase III activity will cleave a double-stranded RNA molecule into short RNA molecules that may trigger or mediate RNAi (siRNA). Compositions of the invention include kits that include an RNase III domain-containing polypeptide. The present invention further concerns methods using polypeptides with RNase III activity for generating RNA molecules that effect RNAi, including the generation of a number of RNA molecules to the same target.
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申请公布号 |
US2004033602(A1) |
申请公布日期 |
2004.02.19 |
申请号 |
US20030460775 |
申请日期 |
2003.06.12 |
申请人 |
AMBION, INC. |
发明人 |
FORD LANCE P.;BROWN DAVID |
分类号 |
A01N43/04;A61K31/07;A61K48/00;C07H21/04;C12N;C12N9/22;C12N15/11;C12N15/85;C12Q1/68;(IPC1-7):A61K48/00 |
主分类号 |
A01N43/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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