发明名称 |
Methods for producing nateglinide crystals |
摘要 |
There is provided methods for producing nateglinide crystals, which comprises the steps of adding an acid(s) to a reaction mixture containing nateglinide to make it acidic, the reaction mixture being obtained by reacting trans-4-isopropylcyclohexylcarbonyl chloride with D-phenylalanine in a mixed solvent of ketone solvent and water in the presence of an alkali; and then adjusting the temperature of the mixture to 58° C. to 72° C. and the concentration of ketone solvent to more than 8 wt % and less than 22 wt % to conduct precipitation of nateglinide crystals. This producing method is the industrially beneficial methods for crystallization of nateglinide.
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申请公布号 |
US2004030182(A1) |
申请公布日期 |
2004.02.12 |
申请号 |
US20030418105 |
申请日期 |
2003.04.18 |
申请人 |
AJINOMOTO CO. INC. |
发明人 |
TAKAHASHI DAISUKE;NISHI SEIICHI;TAKAHASHI SATOJI |
分类号 |
C07C231/02;C07C231/24;C07C233/63;(IPC1-7):C07C231/02 |
主分类号 |
C07C231/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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