| 摘要 |
PROBLEM TO BE SOLVED: To determine a factor for controlling harmful accumulation of matrix components in a pathological stage such as a kidney disease, and control a factor for preventing, restricting or curing pathological conditions including unsuitable accumulation of a matrix. SOLUTION: A method for inhibiting the accumulation of extracellular matrix components in a tissue by bringing the tissue into contact with an agent to control the activity of the transforming growth factorβ(TGF-β) is offered. The agent can be, for example, an anti-TGF-βantibody, a platelet-derived growth factor (PDGF), a peptide containing Arg-Gly-Asp, a decorin or a biglycan with the similar function. COPYRIGHT: (C)2004,JPO
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