发明名称 |
METHOD OF IMMOBILIZING A BIOLOGIC IN A POLYURETHANE-HYDROGEL COMPOSITION, A COMPOSITION PREPARED FROM THE METHOD, AND BIOMEDICAL APPLICATIONS |
摘要 |
A biologic can be immobilized in a transparent polyurethane-hydrogel composition. Such a polyurethane-hydrogel composition can be prepared from forming a polyurethane-hydrogel mixture and immobilizing a biologic in the mixture. The mixture can be formed by admixing a prepolymer and a water-soluble crosslinker in aqueous solvent and in the substantial absence of organic solvent. A suitable prepolymer generally includes at least one water-soluble polyol and at least one isocyanate and can be added to the mixture in an amount of no greater than about 5 weight percent based on total weight of all components. A suitable crosslinker generally has a crosslinker functionality of at least 2. A biologic includes cells, peptides, nucleics, peptide nucleic acids, saccharides, lipopolysaccharides, glycolipids, and combinations of these. A polyurethane-hydrogel composition having an immobilized biologic can be particularly useful for biomedical applications. Some examples of useful biomedical applications include protein microarrays, cell microarrays, and DNA microarrays. |
申请公布号 |
WO03050234(A3) |
申请公布日期 |
2004.02.12 |
申请号 |
WO2002US16140 |
申请日期 |
2002.05.21 |
申请人 |
DOW GLOBAL TECHNOLOGIES INC. |
发明人 |
SANDFORD, ANDREW, F.;SUBRAMANIAN, VENKITESWARAN;ALLEN, JEFFREY, R.;SWANSON, PAUL, E.;STORER, JOEY, W.;SHARMA, DEEPAK, K. |
分类号 |
C08G18/10;C12N11/06;C12N11/08;G01N33/545 |
主分类号 |
C08G18/10 |
代理机构 |
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