| 摘要 |
PROBLEM TO BE SOLVED: To provide a compound which has a calpain-inhibiting activity and a high water-soluble property and is useful as a medicine for preventing and treating ischemic heart diseases, immunological diseases, Alzheimer's disease, osteoporosis, cerebral ischemica, cataract, glaucoma, retinal (chorioidea) disease, retrobulbar area complication (for example, macular edema, detached retinas) due to photocoagulation, and the like, or as a medicine for inhibiting or treating neovascularization and the like. SOLUTION: This pyridine derivative represented by the general formula [R<SP>1</SP>is pyridyl; R<SP>2</SP>and R<SP>3</SP>are each a lower alkyl; (n) is 0, 1 or 2] or its salt. A calpain inhibiter contains the compound. COPYRIGHT: (C)2004,JPO |
