COMPOUNDS THAT INHIBIT HSP90 AND STIMULATE HSP70 AND HSP40, USEFUL IN THE PREVENTION OR TREATMENT OF DISEASES ASSOCIATED WITH PROTEIN AGGREGATION AND AMYLOID FORMATION

摘要

The present invention relates to the use of a compound or a plurality of compounds that inhibit function of Hsp90; or activate expression of both Hsp40 and Hsp70 for the preparation of a pharmaceutical composition for the prevention or treatment of a disease associated with protein aggregation and amyloid formation. Preferably, said compound is geldanamycin. The present invention relates further to methods of producing compounds within proved potency and/or decreased side-effects that may be successfully employed as medicaments for the treatment of said diseases.