Carbamate caspase inhibitors and uses thereof

摘要

This invention provides caspase inhibitors of formula I:wherein Z is oxygen or sulfur; R<1 >is hydrogen, -CHN2, R, CH2OR, CH2SR, or -CH2Y; Y is an electronegative leaving group; R<2 >is CO2H, CH2CO2H, or esters, amides or isosteres thereof; R<3 >is a group capable of fitting into the S2 subsite of a caspase enzyme; R<4 >and R<5 >are taken together with the intervening nitrogen to form heterocyclic ring and R is as described in the specification. The compounds are effective inhibitors of apoptosis and IL-1beta secretion.