发明名称 |
Formulation of adenovirus for gene therapy |
摘要 |
The present invention addresses the need to improve the long-term storage stability (i.e. infectivity) of vector formulations. In particular, it has been demonstrated that for adenovirus, the use of bulking agents, cryoprotectants and lyoprotectants imparts desired properties that allow both lyophilized and liquid adenovirus formulations to be stored at 4° C. for up to 6 months and retain an infectivity between 60-100% of the starting infectivity.
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申请公布号 |
US6689600(B1) |
申请公布日期 |
2004.02.10 |
申请号 |
US19990441410 |
申请日期 |
1999.11.16 |
申请人 |
INTROGEN THERAPEUTICS, INC. |
发明人 |
WU ZHENG;ZHANG SHUYUAN |
分类号 |
A61K9/19;A61K35/76;A61K47/02;A61K47/18;A61K47/20;A61K47/26;A61K47/32;A61K47/38;A61K47/42;A61K47/46;A61K48/00;C12N15/861;(IPC1-7):C12N1/04 |
主分类号 |
A61K9/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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