E-ISOMERIC beta-AROMATIC OR HETEROAROMATIC SUBSTITUTED beta-ACYLAMINO-ACRYLATES AND METHODS OF PREPARING THE SAME

摘要

E-isomeric ss-(hetero) aromatically substituted acylaminoacrylates are of great economic interest since with them, by means of hydration, precursors of appropriately substituted (ss-amino acids can be prepared and, by doing so, lead to higher enantio-selectivities than the corresponding Z-isomers. The invention describes novel E-isomeric R-aromatically or ss-heteroaromatically substituted ss-acylaminoacrylates of the general formula (I): in which R represents hydrogen or a substituted or unsubstituted alkyl or aromatic or heteroaromatic residue, and R' represents a substituted or unsubstituted aromatic or heteroaromatic residue, R" represents H, a substituted or unsubstituted alkyl or aromatic or heteroaromatic residue, and R"' represents H, a substituted or unsubstituted alkyl, acyl, aromatic or heteroaromatic residue. According to the invention, the compounds according to the general formula (I) are prepared by acylation at temperatures below the boiling point of the reaction mixture.