发明名称 |
Chemical reagents for formation of disulfide bonds in peptides |
摘要 |
This invention pertains to the discovery of a class of reagents that effectively form intramolecular disulfide bonds in peptides. Intermolecular disulfide linkage formation is low or essentially non-existent. In addition, preferred reagents of this invention are relatively mild and do not oxidize "vulnerable" residues in the subject peptide(s). In addition the reagents and reaction products are safe and essentially non-toxic. One particularly preferred reagent is [Pt(en)2Cl2]2+ where en is ethylenediamine.
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申请公布号 |
US6686443(B1) |
申请公布日期 |
2004.02.03 |
申请号 |
US20000579883 |
申请日期 |
2000.05.26 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
RABENSTEIN DALLAS L.;SHI TIESHENG |
分类号 |
C07B61/00;C07K1/00;C07K1/107;C07K1/113;C40B40/10;(IPC1-7):A61K38/00 |
主分类号 |
C07B61/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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