Antisense RNA expression strategies effective against Streptococcus thermophilus bacteriophages

摘要

Recombinant bacteria containing nucleotide sequences encoding Streptococcus thermophilus phage helicase and primase genes expressed in the antisense orientation and methods of making and using the same are disclosed. Replication of bacteriophage infecting this bacterial cell, can be inhibited or decreased by constitutively expressing, the antisense oligonucleotide encoding for S. thermophilus phage helicase or primase.