发明名称 |
Expression of somatostatin receptors SSTR1 and SSTR4 on human endothelial cells |
摘要 |
Described is the use of a SSTR1 or SSTR4 (somatostatin receptor subtypes 1 and 4) selective agonist to treat human endothelial cells and to formulate a medicament for human use, where the medicament may be for use to treat an endothelial-cell-mediated proliferative disease. The use of SSTR1 or SSTR4 selective agonists for treating endothelial-cell-mediated proliferative diseases may include, for example, treatment of intimal hyperplasia or an angiogenic disease. In various embodiments, the angiogenic disease may be macular degeneration, or a solid tumour. The SSTR1 or SSTR4 selective agonists may include the SSTR1 '499 agonist (des-AA1,2,5[DTrp8,IAamp9]SS). In methods of treatment, therapeutically effective amounts of the SSTR1 or SSTR4 selective agonists may be administered to a patient.
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申请公布号 |
NZ510543(A) |
申请公布日期 |
2004.01.30 |
申请号 |
NZ19990510543 |
申请日期 |
1999.09.01 |
申请人 |
THE UNIVERSITY OF BRITISH COLUMBIA;QLT INC |
发明人 |
LEVY, JULIA G;MARGARON, PHILIPPE MARIA CLOTAIRE;HSIANG, YORK;BUCHAN, ALISON |
分类号 |
C12N15/09;A61K38/00;A61K38/31;A61K45/00;A61P1/00;A61P1/04;A61P9/00;A61P9/10;A61P17/00;A61P17/02;A61P17/06;A61P27/02;A61P27/06;A61P29/00;A61P35/00;A61P37/00;A61P43/00;C12Q1/02;C12Q1/68;(IPC1-7):A61K38/31 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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