| 摘要 |
A N6 heterocyclic 5' modified adenosine derivative has the formula wherein: X1 is S, S(O) or S(O)2 ; R1 is a monocyclic or polycyclic heterocyclic group containing from 3 to 15 carbon atoms wherein at least one carbon atom is substituted with an atom or molecule selected from the group consisting of N, O, P and S(O)0-2 wherein R1 does not contain an epoxide group and R1 is not linked to the NH group be a heterocyclyl nitrogen atom; R2 is hydrogen, halo, CF3, or cyano; R3 and R4 are each independently hydrogen, (CO)-R', or -(CO)-R"; R' and R" are as defined in the specification; R5 is optionally substituted alkyl, alkenyl, alkynyl, heterocyclyl, aryl or heteroaryl; The compound is an adenosine A1 receptor partial or full agonist, and is useful for modifying cardiac activity, modifying adipocyte function and treating central nervous system disorders, diabetic disorders and obesity. |
