| 摘要 |
Nanostructures are made that include at least one species of assembly unit that is an antibody assembly unit in which at least one joining element, structural element or functional element is an antibody or antibody fragment. Antibody assembly units may have more than one antibody element. In addition, the antibody assembly units may contain non-antibody structural, functional or joining elements. The nanostructure is suitably prepared using a staged assembly method. In this method, a nanostructure intermediate having at least one unbound joining element is contacted with an assembly unit having a plurality of different joining elements. None of the joining elements of the assembly unit can interact with itself or with another joining element of the same assembly unit. However, one of the joining elements of the assembly unit can interact with the unbound joining element of the nanostructure intermediate, so that the assembly unit is non-covalently bound to the nanostructure intermediate to form a new nanostructure intermediate for use in subsequent cycles. Unbound assembly units are removed and the cycles is repeated for a sufficient number of cycles to form a nanostructure. The assembly units in at least one cycle are antibody assembly units.
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