PIPERIDINE DERIVATIVES AND THEIR USE AS SELECTIVE INHIBITORSOF MIP-1ALPHA BINDING TO ITS RECEPTOR CCR1

摘要

A compound of the formula (I) wherein a, b, c R1, R2, R3, R4, R5, R6, R7, Q, W, Y, and Z are defined as above , useful as potent and selective inhibitors of MIP-1.alpha. (CCL3) binding to its receptor CCR1 found on inflammatory an d immunomodulatory cells (preferably leukocytes and lymphocytes).