| 摘要 |
FIELD: organic chemistry, chemical technology, medicine, pharmacy. SUBSTANCE: invention relates to the improved method for preparing compounds of the formula (I): wherein R1 means (C1-C6)-alkyl. Method involves interaction stage of compound of the formula (III) with compound of the formula (IV) indicated in the invention description in the presence of water and metal carbonate. Invention relates also to method for preparing compounds of the formula (II): wherein R1 means (C1-C6)-alkyl; R2 means -(CH2)mB wherein m = 0, 1, 2 or 3; B means phenyl or naphthyl and wherein each among indicated phenyl or naphthyl groups can be substituted with one or some substituents taken independently among chlorine, fluorine, bromine and iodine atom, (C1-C6)-alkyl, (C1-C6)-alkoxy-group, (C1-C6)-alkoxy-(C1-C6)-alkyl, trifluoromethyl, trifluoromethoxy- and cyano-group. Indicated compounds are used as selective agonist and antagonists of serotonin-1 (5-HT1) receptors. Invention provides the enhancement of product yield, degree of its purity and providing its more easily isolation as compared with the nearest analog. EFFECT: improved preparing method. 15 cl, 2 tbl, 5 ex |
