NUCLEOSIDE OR NUCLEOTIDES HAVING NOVEL UNNATURAL BASES AND USE THEREOF

摘要

It is intended to provide a nucleoside or a nucleotide having a novel unnatural base. Namely, a nucleoside or a nucleotide having a 5-substituted- 2- oxo(1H)-pyridin-3-yl group as a base. It is preferable that the base is substituted at the 5-position by a substituent selected from the group consisting of: 1) a photoreactive group selected from between iodine and bromine; 2) an alkenyl group, an alkynyl group, an amino group or a derivati ve thereof; 3) biotin or its derivative; and 4) a fluorescent molecule selected from among fluorescein, 6-carboxyfluorescein, tetramethyl-6-carboxyrhodamine and derivatives thereof.